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Tara Sigdel, Ph.D.

Tara Sigdel, Ph.D.

Assistant Professor
Division of Transplant Surgery

Contact Information

513 Parnassus Ave, Med Sci
San Francisco CA 94143
tara.sigdel@ucsf.edu
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  • B.Sc. (Biology and Chemistry) Tribhuvan University, Kathmandu, Nepal
  • M.Sc. (Chemistry) Tribhuvan University, Kathmandu, Nepal, Advisor: Prof. Vishwanath Pd. Agrawal, PhD
  • Ph.D. (Biochemistry), Miami University, Oxford, OH, Advisor: Prof. Michael Crowder, PhD
  • N/A
  • Postdoctoral Training, Dept of Pediatrics-nephrology, Stanford University, Stanford, CA
  • Advisor: Prof. Minnie Sarwal MD. PhD.
  • Bioinformatics
  • Biomarker DIscovery
  • High Throughput Data
  • Immunology
  • Kidney Transplantation
  • Liver Cancer
  • Organ Transplantation
  • Proteomics

Tara Sigdel, Ph.D. obtained his Ph.D. in biochemistry from Miami University (OH) followed by postdoctoral training in biomarker discovery, immunology, and organ transplantation at Stanford University under Professor Minnie Sarwal. Dr Sigdel joined the UCSF Department of Surgery in 2014 where he uses proteomics, immune response profiling, and gene expression analysis to discover sensitive and effective biomarkers that help in developing clinical tools for early diagnosis and improved patient monitoring. In collaboration with researchers at UCSF and other institutes, Dr. Sigdel is actively involved in identification of non-invasive biomarkers genes, peptides, proteins, and antibodies that monitor disease status after organ transplantation.

  • Pediatric Research Fund – CHRP Award, Stanford University, Stanford, CA, 2009-2010
  • Pediatric Research Fund – CHRP Award, Stanford University, Stanford, CA, 2008-2009
  • Deans Postdoctoral Fellowship, Stanford University, Stanford, CA, 2007-2008
  • Doctoral-Undergraduate Opportunities in Scholarship (DUOS) award for two consecutive years (2003 and, Miami University, Oxford, OH, 2003-2005
  • William Hale Charch Graduate Fellowship, Miami University, Oxford, OH, 2002-2003

Dr. Sigdel's research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.

Most recent publications from a total of 79
  1. Sigdel T, Nguyen M, Liberto J, Dobi D, Junger H, Vincenti F, Laszik Z, Sarwal MM. Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies. Front Med (Lausanne). 2019; 6:213. View in PubMed
  2. Sigdel TK, Yang JYC, Bestard O, Schroeder A, Hsieh SC, Liberto JM, Damm I, Geraedts ACM, Sarwal MM. A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring. PLoS One. 2019; 14(7):e0220052. View in PubMed
  3. Lee BH, Kelly G, Bradford S, Davila M, Guo XV, Amir ED, Thrash EM, Solga MD, Lannigan J, Sellers B, Candia J, Tsang J, Montgomery RR, Tamaki SJ, Sigdel TK, Sarwal MM, Lanier LL, Tian Y, Kim C, Hinz D, Peters B, Sette A, Rahman AH. A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer. Cytometry A. 2019 Sep; 95(9):1019-1030. View in PubMed
  4. Pineda S, Sigdel TK, Liberto JM, Vincenti F, Sirota M, Sarwal MM. Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing. Nat Commun. 2019 04 23; 10(1):1906. View in PubMed
  5. Watson D, Yang JYC, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Louie V, Sigdel S, Livingstone D, Soh K, Chakraborty A, Liang M, Lin PC, Sarwal MM. A Novel Multi-Biomarker Assay for Non-Invasive Quantitative Monitoring of Kidney Injury. J Clin Med. 2019 Apr 12; 8(4). View in PubMed
  6. Yang JYC, Verleden SE, Zarinsefat A, Vanaudenaerde BM, Vos R, Verleden GM, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Watson D, Sarwal MM. Cell-Free DNA and CXCL10 Derived from Bronchoalveolar Lavage Predict Lung Transplant Survival. J Clin Med. 2019 Feb 13; 8(2). View in PubMed
  7. Sigdel TK, Archila FA, Constantin T, Prins SA, Liberto J, Damm I, Towfighi P, Navarro S, Kirkizlar E, Demko ZP, Ryan A, Sigurjonsson S, Sarwal RD, Hseish SC, Chan-On C, Zimmermann B, Billings PR, Moshkevich S, Sarwal MM. Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR. J Clin Med. 2018 Dec 23; 8(1). View in PubMed
  8. Sacreas A, Yang JYC, Vanaudenaerde BM, Sigdel TK, Liberto JM, Damm I, Verleden GM, Vos R, Verleden SE, Sarwal MM. The common rejection module in chronic rejection post lung transplantation. PLoS One. 2018; 13(10):e0205107. View in PubMed
  9. Sigdel TK, Mercer N, Nandoe S, Nicora CD, Burnum-Johnson K, Qian WJ, Sarwal MM. Urinary Virome Perturbations in Kidney Transplantation. Front Med (Lausanne). 2018; 5:72. View in PubMed
  10. Sigdel TK, Nguyen M, Dobi D, Hsieh SC, Liberto JM, Vincenti F, Sarwal MM, Laszik Z. Targeted Transcriptional Profiling of Kidney Transplant Biopsies. Kidney Int Rep. 2018 May; 3(3):722-731. View in PubMed
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