Sarwal Lab »  Lab Members »  Principal Investigators »  Tara Sigdel, Ph.D.
Tara Sigdel, Ph.D.

Tara Sigdel, Ph.D.

Assistant Professor
Division of Transplant Surgery

Contact Information

513 Parnassus Ave, Med Sci
San Francisco CA 94143
tara.sigdel@ucsf.edu
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  • B.Sc. (Biology and Chemistry) Tribhuvan University, Kathmandu, Nepal
  • M.Sc. (Chemistry) Tribhuvan University, Kathmandu, Nepal, Advisor: Prof. Vishwanath Pd. Agrawal, PhD
  • Ph.D. (Biochemistry), Miami University, Oxford, OH, Advisor: Prof. Michael Crowder, PhD
  • N/A
  • Postdoctoral Training, Dept of Pediatrics-nephrology, Stanford University, Stanford, CA
  • Advisor: Prof. Minnie Sarwal MD. PhD.
  • Bioinformatics
  • Biomarker DIscovery
  • High Throughput Data
  • Immunology
  • Kidney Transplantation
  • Liver Cancer
  • Organ Transplantation
  • Proteomics

Tara Sigdel, Ph.D. obtained his Ph.D. in biochemistry from Miami University (OH) followed by postdoctoral training in biomarker discovery, immunology, and organ transplantation at Stanford University under Professor Minnie Sarwal. Dr Sigdel joined the UCSF Department of Surgery in 2014 where he uses proteomics, immune response profiling, and gene expression analysis to discover sensitive and effective biomarkers that help in developing clinical tools for early diagnosis and improved patient monitoring. In collaboration with researchers at UCSF and other institutes, Dr. Sigdel is actively involved in identification of non-invasive biomarkers genes, peptides, proteins, and antibodies that monitor disease status after organ transplantation.

  • Pediatric Research Fund – CHRP Award, Stanford University, Stanford, CA, 2009-2010
  • Pediatric Research Fund – CHRP Award, Stanford University, Stanford, CA, 2008-2009
  • Deans Postdoctoral Fellowship, Stanford University, Stanford, CA, 2007-2008
  • Doctoral-Undergraduate Opportunities in Scholarship (DUOS) award for two consecutive years (2003 and, Miami University, Oxford, OH, 2003-2005
  • William Hale Charch Graduate Fellowship, Miami University, Oxford, OH, 2002-2003

Dr. Sigdel's research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.

Most recent publications from a total of 60
  1. Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. Polyclonal Regulatory T cell Therapy for Control of Inflammation in Kidney Transplants. Am J Transplant. 2017 Jul 04. View in PubMed
  2. Sigdel TK, Sarwal MM. Assessment of Circulating Protein Signatures for Kidney Transplantation in Pediatric Recipients. Front Med (Lausanne). 2017; 4:80. View in PubMed
  3. Crespo E, Roedder S, Sigdel T, Hsieh SC, Luque S, Cruzado JM, Tran TQ, Grinyó JM, Sarwal MM, Bestard O. Molecular and Functional Noninvasive Immune Monitoring in the ESCAPE Study for Prediction of Subclinical Renal Allograft Rejection. Transplantation. 2017 Jun; 101(6):1400-1409. View in PubMed
  4. Pidala J, Sigdel TK, Wang A, Hsieh S, Inamoto Y, Martin PJ, Flowers ME, Hansen JA, Lee SJ, Sarwal MM. A combined biomarker and clinical panel for chronic graft versus host disease diagnosis. J Pathol Clin Res. 2017 Jan; 3(1):3-16. View in PubMed
  5. Nasr M, Sigdel T, Sarwal M. Advances in diagnostics for transplant rejection. Expert Rev Mol Diagn. 2016 Oct; 16(10):1121-1132. View in PubMed
  6. Yang JY, Sigdel TK, Sarwal MM. Self-antigens and rejection: a proteomic analysis. Curr Opin Organ Transplant. 2016 Aug; 21(4):362-7. View in PubMed
  7. Sigdel TK, Gao Y, He J, Wang A, Nicora CD, Fillmore TL, Shi T, Webb-Robertson BJ, Smith RD, Qian WJ, Salvatierra O, Camp DG, Sarwal MM. Mining the human urine proteome for monitoring renal transplant injury. Kidney Int. 2016 Jun; 89(6):1244-52. View in PubMed
  8. Wei C, Sigdel TK, Sarwal MM, Reiser J. Circulating CD40 autoantibody and suPAR synergy drives glomerular injury. Ann Transl Med. 2015 Nov; 3(19):300. View in PubMed
  9. Sigdel TK, Bestard O, Tran TQ, Hsieh SC, Roedder S, Damm I, Vincenti F, Sarwal MM. A Computational Gene Expression Score for Predicting Immune Injury in Renal Allografts. PLoS One. 2015; 10(9):e0138133. View in PubMed
  10. Vitalone MJ, Sigdel TK, Salomonis N, Sarwal RD, Hsieh SC, Sarwal MM. Transcriptional Perturbations in Graft Rejection. Transplantation. 2015 Sep; 99(9):1882-93. View in PubMed
  11. View All Publications
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